• Methotrexate The cellular mechanism underlying the CGS media

  2023-07-05

  

  The cellular mechanism underlying the CGS12066-mediated inhibition of glutamate release from hippocampal nerve terminals through presynaptic 5-HT1B receptors remains to be elucidated. 5-HT1B receptors are coupled to PTX-sensitive G proteins (Gi or Go) that have been shown to inhibit AC activity as w

• br Experimental procedure br Introduction Migraine is a debi

  2023-07-05

  

  Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of

• In conclusion we have produced some highly

  2023-07-05

  

  In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard LFM-A13 KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on corticosteroid

• Previous studies demonstrate that chiral biointerface

  2023-06-27

  

  Previous studies demonstrate that chiral biointerface has great influence on cells adhesion and proteins adsorption [39], [40], [41], [42], [43], which inspired us to further develop antimicrobial materials or surfaces by taking advantage of the “chiral taste” of microbes. L-borneol is a hydrophobic

• The initial demonstration of the potential of MALDI TOF

  2023-06-27

  

  The initial demonstration of the potential of MALDI-TOF MS for testing antifungal susceptibility of pathogenic fungi came from a proof-of-concept study by Marinach et al. [31] who monitored the changes of the proteome of C. albicans LY2584702 exposed to different concentrations of fluconazole. Usin

• The current results also demonstrated tendencies toward decr

  2023-06-26

  

  The current results also demonstrated tendencies toward decreased serum Aβ40 levels and increased Aβ42 levels during the 1-year follow-up. These tendencies are consistent with the results of a previous study that evaluated Aβs in the CSF of patients with late-life depression (Pomara et al., 2016). T

• br Experimental procedures br Results br Discussion br Ackno

  2023-06-25

  

  Experimental procedures Results Discussion Acknowledgments SRE and EBL contributed equally to this WM-1119 work . SRE, EBL, and MJT designed experiments, SRE, EBL, MCH, and AEI conducted experiments, SRE and EBL analyzed data, and EBL and MJT wrote the manuscript. We would like to thank

• sh4 Since the first studies of

  2023-06-20

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other sh4 as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of attention when

• Two cell surface trans membrane receptors have been identifi

  2023-06-19

  

  Two cell-surface trans-membrane receptors have been identified for adiponectin, AdipoR1 and AdipoR2 [21], and adiponectin action is known to signal through these receptors and the docking protein APPL1 [22]. In muscle and liver cells, signal transduction involves the phosphorylation and activation o

• br Acknowledgements We thank Dr Stefan Schulte

  2023-06-13

  

  Acknowledgements We thank Dr. Stefan Schulte-Merker and his group members at the Hubrecht Institute (Utrecht, the Netherlands) for their invaluable support of the zebrafish studies. Our work is supported by grants from the Dutch Cancer Society (KWF) and the Netherlands Organisation for Scientific

• At present the role of autophagy in neurons remains controve

  2023-06-13

  

  At present, the role of autophagy in neurons remains controversial. Autophagy has homeostatic and waste-recycling functions and plays a protective role in neurodegeneration diseases. Moreover, it has been thought as a programmed cell death participating in the occurrence and development of various d

• br Autophagy and cell death pathways in ischemic stroke Alth

  2023-06-13

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic 2 deoxy d glucose injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in

• The identification of novel kinase inhibitor scaffolds

  2023-06-13

  

  The identification of novel kinase inhibitor scaffolds is highly desirable in order to develop selective kinase inhibitors. Small-molecule inhibitors of Interleukin-2-inducible T-cell kinase (Itk) that are based on the 3-aminopyridin-2-one fragment 1 have been reported. Despite derivatisation of 1 y

• br Materials and methods br Results and discussion

  2023-06-07

  

  Materials and methods Results and discussion Conclusions Acknowledgements Introduction Infections in children aged 0–21 years who reside in long-term care (LTC) facilities are common due to underlying complex medical conditions, use of invasive devices such as urinary catheters and ve

• LFM-A13 Recent results suggest that TARPs are not

  2023-06-06

  

  Recent results suggest that TARPs are not the only auxiliary AMPAR subunits. Using a proteomic strategy (affinity purification of native AMPAR complexes followed by mass-spectrometric analysis), cornichon-related proteins (CNIHs) have been recently identified as components of the AMPAR protein micro

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