• br Discussion To our knowledge this

  2024-05-16

  

  Discussion To our knowledge, this is the first case report that demonstrates the presence of a novel T1151K ALK mutation in a patient with disease progression after crizotinib and then ceritinib. As early as 2011, Zhang et al. identified T1151K among other resistance mutations to crizotinib in Ba

• Here we have used transcriptome analysis

  2024-05-16

  

  Here, we have used transcriptome analysis of primary neonatal rat cardiomyocytes treated with either the ETR agonist endothelin-1 or the α1-AR agonist phenylephrine to assess differences in their respective signalling networks, and further probed these differences using a panel of fluorescent resona

• To this the evidence of opposite effects of

  2024-05-16

  

  To this, the evidence of opposite effects of noradrenaline and adrenaline on the striatal firing initiation (Fig. 6, Fig. 7) should not be ignored, because the striatum is related to controlling action timing by regulating the firing increase rate (Tanaka and Kunimatsu, 2011). Although the ligand su

• Our findings establish a critical link

  2024-05-16

  

  Our findings establish a critical link between HemAC-Lm dimeric structure and cAMP synthesis that helps in explaining how globin-A domain influences AC domain. The following possible homodimeric structure of wild type full length HemAC-Lm has been proposed to explain the role of this globin-A domain

• br Effective therapeutic window of AR actions

  2024-05-16

  

  Effective therapeutic window of AR actions on ROP Retinal vasculature undergoes critical developmental changes postnatally: from P7 onward the superficial sodium butyrate mg start sprouting vertically in retina to form first the deep then the intermediated vascular plexus in the retina of C57BL/

• br Introduction Myasthenia gravis MG is an

  2024-05-15

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease characterised by failure of transmission at the neuromuscular junction (NMJ). In 80–85% of myasthenia gravis patients, the disease is mediated by antibodies to the nicotinic endomorphin receptor receptor (AChR; (Lindstrom et al., 1976)

• br Discussion The clinical course

  2024-05-15

  

  Discussion The clinical course of our patient until May 2012 was rather typical of early onset AChR-MG. Later on, the pattern of the disease was more typical of MuSK-MG, as evidenced by the distribution of myasthenic weakness and the unprovoked exacerbations. The HBC of MuSK-MG appears to be cli

• br Materials and methods br Results and

  2024-05-15

  

  Materials and methods Results and discussions Conclusion Fermented camel milk with NS4 exhibited remarkable ACE-inhibitory activity, which revealed its potential application for the preparation of fermented camel milk beverage or fermented camel milk derived peptides in different foods or i

• Introduction hydroxytryptamine HT is found throughout the bo

  2024-05-15

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary T 705 receptor (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current class

• Crohn s disease an inflammatory bowel

  2024-05-15

  

  Crohn’s disease, an inflammatory bowel disease that affects the gastrointestinal (GI) tract, is characterized by a polymorphism in ULK1 autophagy gene due to the presence of single nucleotide polymorphisms (SNPs). Thus, the autophagic process is impaired during the disease. The mutations in the leuc

• The amino hydroxy methyl isoxazolepropionic acid AMPA recept

  2024-05-15

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Manidipine 2HCl (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche,

• A disruption of lung barrier function caused by PM

  2024-05-15

  

  A disruption of lung barrier function caused by PM2.5 has been observed in our experiments; however the underlying mechanism has not been investigated. Zhao et al. (2018) reported that PM2.5 down-regulated the expression levels of tight junction (TJ) proteins and resulted in nasal epithelial barrier

• br Concluding remarks br Definition Prion diseases

  2024-05-15

  

  Concluding remarks Definition Prion diseases are fatal neurodegenerative disorders that are caused by an unconventional agent that is neither bacterial nor viral, but is in essence an infectious misfolded amyloidogenic protein, termed a prion (Prusiner, 1982). Once considered highly controvers

• In Pham et al employed the microsphere based

  2024-05-15

  

  In 2014, Pham et al. [22] employed the microsphere-based technology to create a Luminex probe-based assay for the rapid identification of single nucleotide polymorphisms that are known to confer resistance to one or more echinocandins in C. glabrata. The targets for the FKS probes were generated usi

• Our observation that squalestatin caused only small

  2024-05-15

  

  Our observation that squalestatin caused only small differences in the production of Aβ40 and Aβ42 was in contrast to prior reports of the effects of other cholesterol synthesis inhibitors. This may be due to using squalestatin, a more specific cholesterol synthesis inhibitor that does not affect is

15007 records 100/1001 page Previous Next First page 上5页 96979899100 下5页 Last page