• ERR induces the expression of P

  2019-10-29

  

  ERRγ induces the expression of P450c17 in MA-10 cells and in mouse primary Leydig cells (Fig. 2). Deletion mutant analysis of putative ERRγ-binding sites in the P450c17 promoter suggested that only the proximal third site located between −269 bp and −136 bp within the P450c17 promoter is functional

• Citrus comprising some of the most widely

  2019-10-28

  

  Citrus [29], comprising some of the most widely cultivated fruit crops worldwide, has been consumed as a food and dietary supplement. According to traditional Chinese medicine, dry pericarp of Citrus, as a Chinese herbal remedy, is capable of regulating Qi and expelling phlegm, and has been used to

• Organ fibrosis is thought to be initiated by repeated

  2019-10-28

  

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial pacritinib induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the prof

• br Conclusion and future perspectives LDL

  2019-10-28

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol Dexamethasone the efficacy of cholesterol lowering, both, with statins and with ezetim

• Soon after the discovery of ET and the cloning

  2019-10-28

  

  Soon after the discovery of ET1 and the cloning of its ETA and ETB receptors, low-molecular-weight compounds were identified that can prevent the binding and effects of radioactively labeled ET1 3, 5, 6, 8. Initially, these ERAs resulted from screening efforts (e.g. BQ123 39, 49 and bosentan [50]).

• Although in vitro and in vivo immunosuppressive effects of

  2019-10-28

  

  Although, in vitro and in vivo immunosuppressive effects of female steroids have been described in fish (Yamaguchi et al., 2001, Law et al., 2001), their mode of action was not evaluated in detail. Consequently, it is of considerable interest to investigate the intracellular pathways that regulate t

• It has previously been shown that human melanocytes are resp

  2019-10-28

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of hbv on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that the respon

• The T cell receptor TCR pathway is associated with T

  2019-10-28

  

  The T cell receptor (TCR) pathway is associated with T cell activation and differentiation. When specific antigen peptides are recognized by the TCR, lymphocyte-specific protein tyrosine kinase (lck) phosphorylates the immune-receptor tyrosine-based activation motifs (ITAMs) of the TCR-CD3 complex a

• ion channels Enzyme activity loss during the hydrolysis proc

  2019-10-28

  

  Enzyme activity loss during the hydrolysis process has traditionally been associated with thermal, mechanical, and/or chemical mechanisms (Okino et al., 2013, Ye et al., 2012, Zhang et al., 2010). Due to the recent discovery of enzyme activity loss due to interaction with substrate, it is important

• br Analytical improvements Since our review of Oxysterol Met

  2019-10-28

  

  Analytical improvements Since our review of “Oxysterol Metabolomes” in 2011 [7], there have been a number of improvements in analytical methods for the analysis of oxysterols and related compounds. McDonald and colleagues in Dallas have refined their LC-MS methods which are now applicable for ana

• br General mechanism of NHEJ NHEJ is an

  2019-10-28

  

  General mechanism of NHEJ NHEJ is an amazingly versatile pathway that can select specific enzymes which bind to, process, and finally mediate the direct re-ligation of a wide range of DSBs including those that are complex, have incompatible ends, and contain 6656 damages [7], [8], [9], [10]. Aft

• Because conventional KO mice die within h of

  2019-10-28

  

  Because conventional KO mice die within 24h of birth, it is difficult to analyze higher N6-Methyl-dATP functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discussion O

• Moreover maintaining the pyrimidine pool

  2019-10-28

  

  Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s

• calculating dilutions Introduction PGE is a major mediator p

  2019-10-25

  

  Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 calculating dilutions were able to reverse the swelling a

• Two GPCR subtypes of interest in

  2019-10-25

  

  Two GPCR subtypes of interest in the myocardium are the endothelin receptor (ETR) and the α1-adrenergic receptor (α1-AR). Upon ligand binding, these receptors canonically activate the Gαq protein leading to activation of phospholipase C, hydrolysis of phosphatidylinositol 4,5-bisphosphate into diacy

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