• Additionally both in vitro and in vivo studies showed

  2019-12-05

  

  Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi

• br Activatable MRI probes MRI is

  2019-12-05

  

  Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires Meropenem sale agents to enhance the ima

• In the signaling cascade of innate immunity most of

  2019-12-05

  

  In the signaling cascade of innate immunity, most of the receptor proteins, adaptor proteins, and kinases are modified by ubiquitination to activate and transduce the downstream signaling for efficient production of the IFN and proinflammatory cytokines to combat the pathogens. For example, the K-63

• br Materials and methods br Results br Discussion

  2019-12-05

  

  Materials and methods Results Discussion PYR-41 inhibits UBE1 activity that catalyses an initial step in the ubiquitination reaction. In the present study, we examined the role of this enzyme in sperm-egg fusion by inhibiting UBE1 enzymatic activity in eggs. Our results suggest that PYR-41

• br Materials and methods br Results and

  2019-12-04

  

  Materials and methods Results and discussion Concluding remarks Together, the results of the theoretical kinetic simulations and of the analysis of the experimentally determined kinetic data of SoBADH performed in this work show that ignoring substrate inhibition causes potentially importan

• Lymphocyte mobility and homing is modulated by the chemoattr

  2019-12-04

  

  Lymphocyte mobility and homing is modulated by the chemoattractant receptor subfamily of G protein-coupled receptors (GPCRs) (Campbell et al., 2003, Rot and von Andrian, 2004). B cell migration and position are controlled to a large extent by the lymphoid chemokines CXCL13, CXCL12, CCL19, and CCL21

• Previous studies from our lab looked

  2019-12-04

  

  Previous studies from our lab looked at the effect of interfering with crossover helix interactions in TS-DHFR. One study utilized peptide mimetics of the crossover helix to inhibit wild-type TS-DHFR noncompetitively, and with an IC of 230 μM. A second study used a virtual screening approach to iden

• br Use of recombinant collagen to study DDR collagen interac

  2019-12-04

  

  Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to

• In addition to through direct

  2019-12-04

  

  In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the

• Studies of LRRK tagged with

  2019-12-04

  

  Studies of LRRK2 tagged with green fluorescent protein revealed the presence of monomeric LRRK2 in the ghrelin receptor of living cells, while LRRK2 oligomers were found in the proximity of the plasma membrane, suggesting that both oligomerization status and compartmentalization of LRRK2 defines it

• For the first time the V carinata

  2019-12-04

  

  For the first time, the V. carinata transcriptome was analyzed and its transcript coding sequences comprehensively characterized. The non-redundant contigs encoding putative CysPs were identified and their Sulbactam patterns in different tissues were investigated. Our study show that four proteases

• The significance of the two biomarkers for the detection

  2019-12-04

  

  The significance of the two biomarkers for the detection of Aspergillus antigen and DNA in the sputum of patients cannot be over-emphasised. The mean GMI value was higher among CPA patients than the ABPA. This might not be unconnected with the fact that CPA is associated with lung damage and pre-exi

• Citrus comprising some of the most widely cultivated fruit

  2019-12-04

  

  Citrus [29], comprising some of the most widely cultivated fruit crops worldwide, has been consumed as a food and dietary supplement. According to traditional Chinese medicine, dry pericarp of Citrus, as a Chinese herbal remedy, is capable of regulating Qi and expelling phlegm, and has been used to

• br Discussion This study characterized longitudinal changes

  2019-12-04

  

  Discussion This study characterized longitudinal changes of cholinesterase and PON1 enzyme activities in greenhouse workers over two periods of a crop season with different levels of pesticide exposure. Although study participants were not exposed to OP insecticides, because they worked under int

• In our xenograft study Fig Fig we observed that DYD

  2019-12-04

  

  In our xenograft study (Fig. 7, Fig. 8), we observed that DYD acts very similarly to progesterone; the initial faster tumor growth in the PGRMC1-transfected MCF7 tumor was not significant compared with that with progesterone, in HBTU sale to the greater tumor growth observed with norethisterone. Th

15708 records 917/1048 page Previous Next First page 上5页 916917918919920 下5页 Last page