• The finding that CRF facilitated escape performance both in

  2020-07-28

  

  The finding that CRF facilitated escape performance both in the dmPAG and dlPAG contrasts with previous evidence showing a columnar differentiation on the effects of this peptide in the rat elevated plus-maze. More specifically, Borelli and Brandao (2008) showed that CRF caused anxiogenic effect aft

• br Discussion Taken together our results demonstrate

  2020-07-28

  

  Discussion Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 woul

• Our module is designed to allow in process measurement of

  2020-07-28

  

  Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a Cy3 maleimide (non-sulfonated) receptor detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak analysis of the chromatographic data u

• Introduction Activation of epidermal growth factor receptor

  2020-07-27

  

  Introduction Activation of epidermal growth factor receptor (EGFR)-receptor tyrosine kinases (RTKs) is a key factor in the progression of non-small cell lung cancer (NSCLC). EGFR-RTKs cause proliferation, invasion, metastasis, and angiogenesis, as well as suppress apoptosis, in lung adenocarcinoma

• LIPG plays a key role in numerous female cancers including

  2020-07-27

  

  LIPG plays a key role in numerous female cancers, including breast cancer (Yu, Han, Wolfson, & Zhou, 2018). LIPG is up-regulated in women with menopausal symptoms and plays a role in lipid metabolism, inflammatory responses, and tumor progression (Muzzio et al., 2007, Rathnayake et al., 2018). DKK1

• br Acknowledgments br Introduction Cysteinyl leukotrienes

  2020-07-27

  

  Acknowledgments Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic dpp-4 inhibitor and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranluk

• br Results br Discussion Nuclear export

  2020-07-27

  

  Results Discussion Nuclear export of vRNP was originally thought to be mediated by the NEP/CRM1 interaction (O\'Neill et al., 1998), but several later studies indicated a role for NP in vRNP nuclear export: for example, LMB inhibits nuclear export of vRNP in a NEP-independent manner (Elton et

• br Conclusion and future perspectives br

  2020-07-27

  

  Conclusion and future perspectives Conflict of interest Acknowledgments This work was supported in part by grants from the National Institutes of Health (CA49639, 100632, CA136411, and CA16672), the Paul and Mary Haas Chair in Genetics (all to M.A.), and the Japan Society for the Promotion

• In this study we further investigated

  2020-07-27

  

  In this study, we further investigated the involvement of CRF1 and CRF2 receptors of the dPAG in the regulation of panic-related responses. For this, we used two animal models that associate escape behavior with panic attacks: the elevated T maze and the electrical stimulation of the dPAG (for a ful

• Although the aforementioned studies indicate that increased

  2020-07-27

  

  Although the aforementioned studies indicate that increased CRF and noradrenergic transmission plays a role in drug withdrawal, very few studies have investigated the role of CRF and noradrenergic transmission in the central nucleus of the amygdala (CeA) in nicotine dependence. The present studies i

• br Introduction Protein kinase C PKC is

  2020-07-27

  

  Introduction Protein kinase C (PKC) is a prototypical class of serine/threonine kinases and influences a variety of cellular events such as cell proliferation, cell cycle, differentiation, survival, migration, and polarity [1], [2], [3]. PKC was originally identified as a cellular receptor for th

• As noted by the authors a limitation of this study

  2020-07-27

  

  As noted by the authors, a limitation of this study is that alternative activation of CPT1a-deficient macrophages was only assessed in vitro. An important question is how macrophage-specific CPT1a-deficient mice behave in vivo in situations like asthma, helminth infections, wound healing, and tumors

• The collagen field undoubtedly regains attractiveness with

  2020-07-27

  

  The collagen field undoubtedly regains attractiveness with the emergence of new concepts (cell niche, regulation of growth factor bioavailability, mechanotransduction, cell microenvironment sensing) and new tools to investigate their in vivo functions (atomic force microscopy (AFM), second harmonic

• br Introduction The dopaminergic system and its projections

  2020-07-25

  

  Introduction The dopaminergic system and its projections including both the prefrontal SB 290157 trifluoroacetate salt (PFC) and striatum are known as being crucial to synaptic plasticity, skill acquisition and higher order functions (e.g., working memory and cognitive control; Matsumoto et al.,

• The present study has shown that

  2020-07-25

  

  The present study has shown that additional protein stability can be achieved (Fig. 6). The 0.6 to 1.0 °C increases that were observed were not large compared, for example, to the ∼5 °C increase that has been reported using sequence modifications [22]. This may reflect that the Hyp enters both the X

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