• The inclusion of unstained socks in washes with semen

  2020-08-05

  

  The inclusion of unstained socks in washes with semen-stained clothing provides preliminary data of secondary transfer of DNA from the stained items of clothing to unstained items. Complete DNA profiles matching that of the semen donor were found on the majority of the socks (Table 3). This finding

• br Experimental Procedures br Author

  2020-08-05

  

  Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s

• Then we further studied the relationship between ERR and

  2020-08-05

  

  Then we further studied the relationship between ERRγ and HSD17B1. ERRγ has been shown to have critical regulatory roles in various tissues as a result of its binding directly to ERREs in the promoter regions of VEGFA, BMP2, KCNE1, and KLK1 [17,36,37]. In the present study, we showed that ERRγ also

• The second challenge is to identify biomarkers that accurate

  2020-08-05

  

  The second challenge is to identify biomarkers that accurately forecast treatment outcome [134]. Our institutional experience from several advanced cancers suggests that therapies matching underlying actionable somatic mutations can improve outcomes compared to unmatched therapies [135]. Unfortunate

• BPTES br Acknowledgements This work was

  2020-08-05

  

  Acknowledgements This work was supported by the Center of Innovation Science and Technology based Radical Innovation and Entrepreneurship Program (COI STREAM) of the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) in Japan. We would like to thank Editage (www.editage.jp) fo

• Similarly research ranking RESEARCH was not significant in

  2020-08-04

  

  Similarly, research ranking (RESEARCH) was not significant in the model so H7 is not supported. Contrary to the findings of Bline et al., 2016b, Boone et al., 2006, the current study did not find an association between faculty research productivity and exam pass rate. This could be due to difference

• br Conclusion In conclusion we have provided

  2020-08-04

  

  Conclusion In conclusion, we have provided evidence that the α1-AR family activates the cAMP/PKA pathway in a Gαs-dependent manner. Within this subfamily, there is subtype specific activation of PKA in various cellular compartments. Furthermore, the inability of the ETAR to activate PKA highlight

• Dorsomorphin receptor br Introduction Sunflower Helianthus a

  2020-08-04

  

  Introduction Sunflower (Helianthus annuus L.) heterotrophic seeds, photosynthetically inactive during their development, rely completely on the maternal supply from photosynthetic tissues for building up reserves. Photosynthetic sucrose is exported to sink tissues providing the majority of carbon

• br Materials and methods br Results

  2020-08-04

  

  Materials and methods Results We have previously demonstrated that 4 days of retinol pretreatment (75 mg/kg/day) potentiates paracetamol-induced hepatotoxicity in the male Swiss Webster mouse (Rosengren et al., 1995). We have replicated this finding in another strain, the BALB/c mouse (Fig. 1)

• The canonical BCL repressive mechanism of action in

  2020-08-04

  

  The canonical BCL6 repressive mechanism of action in GC apiii is mediated by recruitment of the SMRT, NCOR, and BCOR corepressors to the BCL6 BTB domain (Hatzi and Melnick, 2014). However, we find that Bcl6 BTB mutant mice are still mostly capable of forming early GC clusters. This phenotype is in c

• br Conclusions br Conflict of

  2020-08-04

  

  Conclusions Conflict of interest Acknowledgments This research was supported by International Society of Hypertension (ISH) grant for mentors (2017) and Association of African Universities (AAU; 2017). Introduction Standard treatment for hypoglycemia is administration of dextrose but i

• The photocleaving properties of were studied by performing X

  2020-08-04

  

  The photocleaving properties of 1 were studied by performing ΦX174 photocleavage assays. Light irradiation of the mixtures of increasing amounts of 1 with supercoiled DNA caused>90% supercoiled form relaxation and approximately 5% of linearization for the higher concentrations of 1 (1:10bp and 1:2b

• br The involvement of DNA PK in the inflammatory

  2020-08-03

  

  The involvement of DNA-PK in the inflammatory response Protein complex, NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) regulates many genes involved in mammalian immune and inflammatory responses, apoptosis, cell proliferation, and differentiation in response to stimuli su

• Based on shared structural motifs DGK isoforms in multicellu

  2020-08-03

  

  Based on shared structural motifs, DGK isoforms in multicellular organisms are classified into five subtypes. Because most of these organisms express at least one DGK ortholog of each subtype, the five DGK subtypes appear to have distinct functions. Nine mammalian DGK isoforms have been identified (

• The nucleus has a phosphatidylinositol cycle that is

  2020-08-03

  

  The nucleus has a phosphatidylinositol cycle that is regulated separately from the plasma membrane PI signalling [74]. Like its extranuclear counterpart, nuclear DAG signalling appears to be compartmentalized. Indeed, D\'Santos et al. [75] demonstrated independently fluctuating pools of nuclear DAG

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