• In the past few years we and others

  2021-04-21

  

  In the past few years we and others have reported that GLP-1 may also be secreted by sub-populations of alpha carnitine palmitoyltransferase in human pancreatic islets (Marchetti et al., 2012, Ellingsgaard et al., 2011), which could contribute to beta cell function and survival (Marchetti et al., 20

• br Conclusion br Conflict of interest br Acknowledgment The

  2021-04-21

  

  Conclusion Conflict of interest Acknowledgment The authors acknowledge the grant support of the Tehran University of Medical Sciences (94-02-49-29647). Introduction Earlier in vitro observations have also established that the human 5-HT2A, while very similar to the rat isoform, exhibits

• Aldehyde dehydrogenase has been characterized as a cancer

  2021-04-20

  

  Aldehyde dehydrogenase has been characterized as a cancer stem cell marker, which plays a key role in various biological processes in tumor, including cell proliferation, invasiveness and chemoresistance. Recent data of Abourbih et al reported that ALDH1 expression did not correlate with primary tum

• In cancer interactions between the transformed cancer cells

  2021-04-20

  

  In cancer, interactions between the transformed cancer NMS-1286937 mg and other cell types recruited to the tumor are important. Tumor associated macrophages provide cancer cells with a suitable low-grade inflammatory milieu including growth promoting factors. Our results suggest a novel pro-tumori

• br Acknowledgment We thank Professor Yuh Chang Sun for

  2021-04-17

  

  Acknowledgment We thank Professor Yuh-Chang Sun for providing helpful advice and the Ministry of Science and Technology of the Republic of China for financial support (grants MOST ). Introduction Past century has witnessed a tremendous increase in life expectancy of the human population, achi

• br Conclusion In this study we investigated functional alter

  2021-04-17

  

  Conclusion In this study, we investigated functional alterations of ECs following exposure to mechanical and/or physicochemical stimuli. Specifically, hypoxia induced phosphorylation with significant increases after 30 min and the maximum increase was after 180 min. Our data show that a combinati

• In conclusion we demonstrate that

  2021-04-15

  

  In conclusion we demonstrate that infection of salmon cells with ISAV induce the main branches of the cellular UPR machinery, but also one of its main negative regulators, GADD34. This is probably important for maintaining translation of interferon and interferon stimulated genes (ISGs), keeping ISA

• E is encoded by the largest and

  2021-04-14

  

  E1 is encoded by the largest and most conserved open-reading frame (ORF) of the PV genome. The protein ranges in size from 600 to 650 amino acids, depending on the PV type. Overall, the protein can be divided into three functional segments: an N-terminal regulatory region that is essential for optim

• DDR is characterized by an N terminal discoidin

  2021-04-14

  

  DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of expression level in cancer tissues and biological functions in normal and cancer cell conditions, but char

• br Introduction The stroma associated with breast cancer met

  2021-04-14

  

  Introduction The stroma associated with breast cancer metastasis consists of extracellular matrix (ECM) proteins, including fibrillar collagens, and a cellular component comprised of mesenchymal stem/multipotent stromal autumn wind (MSCs), vessels, and cells of the immune system (Pein and Oskars

• br Introduction Noncanonical nucleoside triphosphates NTPs s

  2021-04-14

  

  Introduction Noncanonical nucleoside triphosphates (NTPs; such as deoxyinosine triphosphate (dITP), deoxyxanthosine triphosphate (dXTP), 8-oxo-deoxyguanosine triphosphate, and 2-oxo-deoxyadenosine triphosphate are produced from oxidation, deamination, or other modifications of canonical nucleotid

• pannexin-1 inhibitor In this review we first

  2021-04-14

  

  In this review, we first introduce the in vivo metabolism profile of VD3, and the mediation of Cyp3a gene transcription by PXR and CAR in humans, mice and rats. We then focus on the species-specific VDR-dependent regulation of human (CYP3A4, CYP3A5 and CYP3A7), mouse (mainly CYP3A11 and CYP3A13), an

• Our structures also provide new

  2021-04-14

  

  Our structures also provide new insights into CRTH2 drug development. The ligand binding pocket revealed by our structures comprises many aromatic residues and a few polar residues at the distal end. Correspondingly, most CRTH2 antagonists share a similar structural feature characterized by an aceta

• The mammalian two hybrid results described

  2021-04-14

  

  The mammalian two-hybrid results described above were all obtained in 293T cells, and thus the higher RLU observed specific to the hCrm1 fusion could be consistent with human lactone having an unknown activator that interacts with hCrm1 HEAT repeat 9A and somehow facilitates Crm1-Rev/RRE function.

• Third we also found negative correlations between TREM

  2021-04-14

  

  Third, we also found negative correlations between TREM2 mRNA expression and the methylation rate of 4 CpG sites in the intron 1 of TREM2. Gene methylation rates are generally associated with gene expression. Thus, heavily methylated areas of genes are usually less active at the transcriptional leve

15340 records 643/1023 page Previous Next First page 上5页 641642643644645 下5页 Last page