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On the opposite side sPLA X has also been
2021-03-18
On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer Otilonium Bromide receptor and promotes their survival during nutrient stress. It acts through the produc
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Upon Edn ligand binding endothelin receptors can induce a va
2021-03-18
Upon Edn ligand binding, endothelin receptors can induce a variety of intracellular signaling cascades leading to diverse cellular responses such as contraction in the case of smooth muscle cells, or cell growth and mitogenesis. Ednrs are expressed in a variety of cell types and tissues, for example
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br Author contribution br Acknowledgements We want
2021-03-18
Author contribution Acknowledgements We want to thank Dr. Manuel Rodriguez, Dr. Ch. Blattner, Dr. Jorge Moscat, Dr. Erwin Knecht and Dr. Peter Tontonoz for materials. This work has been supported by grants from the Spanish Ministry of Education and ScienceSAF2011-27442 and a grant from General
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In attempts to further purify His Artemis numerous matrices
2021-03-18
In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and BIX 01294 interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP)
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br Materials and methods br Statistical
2021-03-18
Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein Cyclophosphamide data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data
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Previous studies found that depression primarily results
2021-03-18
Previous studies found that depression primarily results from impaired monoaminergic neurotransmission systems [1], [2]. The glutamatergic and GABAergic systems as well as several neuropeptide systems have also been the focus of pathophysiological studies on depression [1], [2]. Inflammatory cytokin
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Supported by the Austrian Science Fund
2021-03-18
Supported by the Austrian Science Fund FWF (grant P22521-B18 to A.H.) and the Austrian National Bank (grant 14263 to A.H.). K.J. was funded by the PhD Program DK-MOLIN (FWF-W1241). Acknowledgements Introduction Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), a more sev
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Almost all previously published haplotype association studie
2021-03-18
Almost all previously published haplotype association studies have demonstrated the importance of haplotype reconstruction because the combinations of SNPs exert synergistic effects on protein function. Even synonymous polymorphisms within haplotypes can have functional consequences that are drastic
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Carbonization and decarbonation are two different phases in
2021-03-17
Carbonization and decarbonation are two different phases in the decomposition of rice husk. Silica in RHA melts around 1440°C [5]. Burning of rice husk at temperature lower than 800°C produces reactive amorphous silica which contains approximately 90% silica, whereas above this temperature some crys
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Previous studies demonstrated that cPLA translocates to
2021-03-17
Previous studies demonstrated that cPLA2α translocates to the phagosomal membrane during macrophage phagocytosis through mechanisms that, in humans, involve phosphorylation of the enzyme by c-Jun N-terminal kinases and membrane association via the cationic cluster of four lysine residues present at
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br Acknowledgments br Introduction br Endothelin receptors S
2021-03-17
Acknowledgments Introduction Endothelin receptors Shortly after the discovery of ET‐1, two types of seven transmembrane G protein‐coupled receptors were cloned called endothelin receptor A (ETA) (Arai et al., 1990) and ETB (Sakurai et al., 1990). The affinity of the ETA receptor for ET-3 is
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br Conflict of interests br Introduction Ubiquitylation is a
2021-03-17
Conflict of interests Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dy
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br Acknowledgments br Introduction Ubiquitin ligases limit t
2021-03-17
Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr
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Silvestrol br Effect of DPP Inhibitors on the Clinical Cours
2021-03-17
Effect of DPP-4 Inhibitors on the Clinical Course of Heart Failure Four large-scale cardiovascular outcomes trials with DPP-4 inhibitors have been completed, and their findings have been published (Table 1) 31, 32, 33, 34. In 2 studies (with saxagliptin and alogliptin), DPP-4 inhibition was accom
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A great deal of research
2021-03-17
A great deal of research has focused on candidate medications to modulate dopaminergic mechanisms through which psychomotor stimulants produce addictive effects, i.e., drugs that expressly target the DA transporter, D1-like receptor, or D2-like receptors., , However, effective dopaminergic-based ph
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