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br DGKs inhibition and signaling Local DAG
2021-09-01
DGKs inhibition and signaling Local DAG levels are strictly controlled by a balance between synthesis and degradation rates. Both receptor controlled PLC-mediated production and DGK-mediated degradation are classically implicated in the control of “signaling” DAG. However, this dogma is starting
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br Signaling of DDR receptor and its regulation
2021-09-01
Signaling of DDR2 receptor and its regulation Being the tyrosine kinase receptor, downstream signaling of DDR2 receptor is initiated by phosphorylation of cytoplasmic tyrosine residue upon ligand binding (Type II collagen) but the authentic facts or detail information of tyrosine phosphorylation
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DDI is one of the main problems
2021-09-01
DDI is one of the main problems with serious clinical consequences in clinical settings. Several reports have highlighted the role of modulation of drug-metabolizing enzymes, especially CYP450 s, as a major mechanism involved in clinical DDIs [3,4,7]. The present study aimed to investigate the effec
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Many investigators participated in the studies on the regula
2021-09-01
Many investigators participated in the studies on the regulation of the smad pathway and experiments indicated that the process was conserved across many eukaryotic species including humans [127]. Because cancer cells exhibit dysregulated cell division along with the presence of abnormal chromosome
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The early serologic response of infants to infection
2021-09-01
The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV ppar agonist produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonata
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Finally we have determined for the first
2021-09-01
Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent A 419259 trihydrochloride synthesis receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cul
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In this regard http www
2021-09-01
In this regard, some attempts have been made to reduce the presence of those radicals. In presence of fluorine source, it seems that the fluorine atoms can substitute the hydrogen atoms linked to silicon atoms, forming Si-F bonds with a higher bonding Ciclopirox ethanolamine synthesis (536 kJ mo1−1
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br Materials and methods br Results br
2021-09-01
Materials and methods Results Discussion DAS and nilotinib, as the second potent, oral generation TKIs, bind to both the active and inactive conformation of the ABL1 kinase domain, have been found to be effective in treating patients with IM resistant or intolerant CML-CP, and inhibit all t
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Quantum dots QDs which exhibit excellent fluorescence quantu
2021-09-01
Quantum dots (QDs), which exhibit excellent fluorescence quantum yields (QYs), high extinction coefficients and size-tunable narrow emission have highly attracted great interest in various applications such as in solar cells, sensors, and bioimaging [16], [17], [18], [19], [20]. However, QDs suffere
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Materials and methods br Results Assay
2021-09-01
Materials and methods Results Assay of botulinum toxin activity is critical for the risk-assessment, diagnosis, and treatment of botulism cases. The frequently encountered active forms of the toxin are; L chain (inside intoxicated neuronal cells), BoNT (in the blood stream of a botulism patient,
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The best characterized APC C substrates are recruited via
2021-09-01
The best-characterized APC/C substrates are recruited via various linear motifs (e.g., D boxes, KEN boxes, and ABBA motifs) that serve as degrons, binding to distinct regions of the β-propeller domain of a coactivator (Figure 1, Figure 3B) (reviewed in [44]). In addition, D boxes also simultaneously
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Although PQQ has nutritional importance
2021-08-31
Although PQQ has nutritional importance and pharmacological effects in higher organisms, including humans [15], until recently, there was no clear evidence for the use of PQQ as a co-factor in a eukaryotic enzyme. This review presents a novel eukaryotic PQQ-dependent quinohemoprotein recently discov
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It has been shown that DAPK induces cell
2021-08-31
It has been shown that DAPK induces cell death through an increase in DAPK catalytic activity and subsequent phosphorylation of target proteins (Shang et al., 2005, Yamamoto et al., 2002), but its multidomain structure enables also a close physical interaction with other proteins (Bialik and Kimchi,
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CYP s are heme containing
2021-08-31
CYP450s are heme-containing monooxygenases constituting a conserved gene superfamily of heme-thiolate proteins, and are found in prokaryotes and eukaryotes (Martignoni et al., 2006). They play a key role in detoxification of endogenous (e.g., steroids) and exogenous compounds (e.g., drug, insecticid
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Cy5 EGFP mRNA In solid tumors such as
2021-08-31
In solid tumors, such as those in breast and pancreatic cancer, infiltrating CD68+ or CD163+ tumor-associated macrophages (TAMs) correlate with poor outcome (DeNardo et al., 2011, Kurahara et al., 2011, Shabo et al., 2008). The tumor-promoting function of TAMs is based on their capacity to secrete p
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