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Historically pharmacological investigations have been carrie
2021-09-27
Historically, pharmacological investigations have been carried out by first identifying a biological response to a ligand, and then subsequently using that ligand to identify the receptor(s) responsible for the response (Wilson et al., 1998). However, this approach needed revision with the discovery
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KYNA has been shown to regulate iNKT cytokine release
2021-09-27
KYNA has been shown to regulate iNKT cytokine release (Fallarini et al., 2010) and at high concentrations to reduce LPS-induced TNFα release from cultured peripheral blood mononuclear CCT007093 (Wang et al., 2006). Our results show that elevating KYNA to “exercised” levels is sufficient to promote a
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br Discovery of GPR A
2021-09-27
Discovery of GPR109A The murine niacin receptor, protein upregulated in macrophages by interferon-γ (PUMA-G), was identified as a G-protein-coupled receptor (GPCR) expressed in adipocytes and spleen [22], [23]. This finding suggested a role of this receptor in macrophage function [24]. In 2003, t
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CF patients can suffer from a multitude of hepatobiliary
2021-09-27
CF patients can suffer from a multitude of hepatobiliary problems including gall stones, hepatitis, steatosis and cirrhosis. Hepatobiliary problems are common in pediatric CF patients with reported prevalence rates up to 25% [12,13]. Cystic fibrosis related liver disease (CFLD) was thought to develo
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Overall our results indicated the involvement of GABAAR
2021-09-27
Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G
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BCCA occlusion followed by reperfusion injury significantly
2021-09-27
BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral PD 151746 sale during ischemia [34,35]. The gene expression of brain AT2 receptor is increased in
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Despite potent biological actions the native hormone undergo
2021-09-26
Despite potent biological actions, the native hormone undergoes degradation by the enzyme dipeptidylpeptidase-IV (DPP-IV) [17] and is rapidly cleared from the bloodstream by renal filtration [18]. One such approach to prolong the biological half-life of GIP is through conjugation with a polyethylene
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br GJs in the brain br Alterations
2021-09-26
GJs in the brain Alterations of GJs in epilepsy The role of GJ blockers and openers in epilepsy As previously known, GJ-mediated electrical coupling plays a role in the generation of highly synchronous electrical activity. The hypersynchronous neuronal activity is a significant feature of c
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The effects of galanin on anxiety may depend on the
2021-09-26
The effects of galanin on anxiety may depend on the site of drug administration, on the galanin receptor subtypes activated and on the animal models of anxiety employed (Barrera et al., 2005, Holmes and Picciotto, 2006, Soares et al., 2016a, Soares et al., 2016b). For instance, administration of gal
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br Introduction Conversion of visual input into electrical
2021-09-26
Introduction Conversion of visual input into electrical information and routing this information to the brain is the main function of the eye (Levin et al., 2011). These processes require a microenvironment that offers adequate supply with oxygen and nutrients and also removal of all unwanted and
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Propylthiouracil In summary two new flexible amine functiona
2021-09-26
In summary, two new flexible amine-functionalized quinolinium derivatives with far-red region emitting were prepared. The shorter-chain fatty amine side chain in the scaffold of was found to be a more promising G-quadruplex DNA fluorescent probe, suggesting the amine side group plays an important ro
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Lidocaine Of the cases identified herein three known
2021-09-26
Of the 52 cases identified herein, three known and 11 novel FGFR fusion partners were identified. Notably, an oligomerization domain, including coiled-coil dimerization domains similar to that seen in echinoderm microtubule associated protein like 4 gene (EML4), which is the most common ALK partner
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Plasmid construction and site directed mutagenesis of M lute
2021-09-26
Plasmid construction and site-directed mutagenesis of M. luteus B-P 26 UPS. For the expression of N-terminus His6-tagged M. luteus B-P 26 UPS, the expression plasmid pMluUEX [7] was cleaved with the restriction enzymes NdeI/BamHI. The gene fragment was inserted into an NdeI/BamHI-treated pET-15b to
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br Development of calibrators and controls for
2021-09-26
Development of calibrators and controls for DiXaIs Method validation and comparison with reference technique (LC:MS) At this stage, anti-Factor Xa bioassays can be established for reliably measuring DiXaI concentrations in plasma, with the available appropriate drug specific calibrators and co
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In addition the interplay of
2021-09-26
In addition the interplay of membrane curvature induced tension at the fusion pore and Eribulin mesylate receptor induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity wa
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