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The combination of niacin with a selective PGD receptor anta
2021-10-13
The combination of niacin with a selective PGD2 receptor antagonist laropiprant, designed to circumvent the flushing side effect of niacin, has been evaluated in the HPS2-THRIVE study and showed no clinically meaningful benefit when administered in patients on top of statin therapy [41]. Our data su
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We were able to obtain
2021-10-13
We were able to obtain several crystalline forms of CHAV Gth. The first one corresponded to the post-fusion conformation [14]. The comparison of this structure with that of VSV-Gth post-fusion conformation revealed that the PHD is the most divergent domain, with the largest differences confined to t
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Experiments conducted on the human parasite Leishmania major
2021-10-13
Experiments conducted on the human parasite Leishmania major has shown that specific parasitic antigens are involved in steering the immune responses to “protective” as opposed to “disease” state (Reiner et al., 1993; Reiner and Locksley, 1995; and Sjölander et al., 1998) and that antigenic composit
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Overnight mg dexamethasone suppression testing DST
2021-10-13
Overnight 1-mg dexamethasone suppression testing (DST) of the BclI polymorphism carriers found them to have lower cortisol levels, suggesting an increased sensitivity to GCs with respect to the transrepression effect of cortisol on the POMC gene of the corticotroph pituitary cells [28]. The exact me
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CC-10004 Animal studies have shown that various antidepressa
2021-10-13
Animal studies have shown that various antidepressant treatment are capable of upregulating GR protein and mRNA in key CC-10004 regions including the hippocampus and decreasing basal and/or stress-induced glucocorticoid secretion [37]. Changes in the level or function of GR regulate the negative fe
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At the end of experiments rats were injected
2021-10-13
At the end of experiments rats were injected high dose of sodium pentobarbital (90mg/kg) and the rat’s head was cut and frozen in −20°C for 20min with the injecting tube in situ before section. The location of the tip of the injecting tube was verified and all the tips of the injecting tube were in
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Inflammasomes are multimeric protein complexes involved in t
2021-10-12
Inflammasomes are multimeric protein complexes involved in the host defense protecting activity against invading pathogens and in physiological aberrations such as cancer and auto-inflammatory, metabolic, and neurodegenerative diseases. Inflammasomes induce the inflammatory process by triggering the
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PD-1/PD-L1 Inhibitor 3 Sperm exocytosis or acrosome reaction
2021-10-12
Sperm exocytosis or acrosome reaction (AR) is a regulated secretion with special characteristics essential for fertilization. The AR relies on the same highly conserved molecules that drive intracellular membrane fusion and exocytosis in all other PD-1/PD-L1 Inhibitor 3 (see [59] for a recent revie
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Describing histone acetylation machinery in rivulus will pro
2021-10-12
Describing histone acetylation machinery in rivulus will provide a basis for understanding the role of epigenetic mechanisms in mediating phenotypic variation, by guiding both phenotypic flexibility in adults and developmental plasticity in young. Together with its biological characteristics, rivulu
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Treatment with histamine had no effect on
2021-10-12
Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 8-Bromo-cGMP, sodium salt sale (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor regulate
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A two way chi square test was used
2021-10-12
A two-way chi-square test was used to determine statistically significant differences between corresponding frequencies of GT results for the 2 testing periods. A p value of Results Distribution of HCV GT results obtained during the 2 study periods are shown in Table 1. While very low frequencies
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Polyunsaturated fatty acid components of brain
2021-10-12
Polyunsaturated fatty gonadotropin releasing hormone agonist components of brain are more prone to oxidative attack, an event called lipid peroxidation. Consistent with previous findings on neurotoxicity [58,59], colistin sulphate increased the level of MDA in the brain of rats. The elevated MDA, a
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br Conclusions br Acknowledgments This work
2021-10-12
Conclusions Acknowledgments This work was financially supported partly by Shanghai Pujiang Talent Project (No.: 08PJ14017), the National Natural Science Foundation of China (Nos.: 20771029 and 91013001) and Shanghai Leading Academic Discipline Project (No. B108). Soluble guanylate cyclase (
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br Investigations br Genetics GLUT is a membrane
2021-10-12
Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, auda microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, located on chromosome 1
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The modulation of the activity of the Gardos channel
2021-10-11
The modulation of the activity of the Gardos channel by the chemokines IL-8 and RANTES was observed in the Duffy-positive but not in the Duffy-negative SSRBCs. This finding is consistent with the previous observation on normal red blood Triflusal (AARBCs) described by Rivera et al. [10]. Altogether
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