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br Introduction Glucokinase GCK hexokinase IV is a
2021-12-29
Introduction Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step of glycolysis in the liver and pancreas [1,2]. GCK was first discovered in the early 1960's, and shortly thereafter i
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In this study we saw change in GHS R a
2021-12-28
In this study, we saw change in GHS-R1a mRNA expression in fasting condition. It is noteworthy that changes in ghrelin and GHS-R1a mRNA expression synchronized in organs were examined. In the Kaempferol-3-rutinoside and pituitary, gene expression increased 4days after fasting, and the increased lev
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At present many methods have been applied for multiple detec
2021-12-28
At present, many methods have been applied for multiple detection. For example, CHIR-090 [[9], [10], [11]] is frequently used to detect multiple targets because of its exquisite sensitivity and specificity, but it is difficult to design experiments to test short-length oligonucleotides. Electrochem
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br Summary The presented results of the
2021-12-28
Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste
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Based on the previous report that FXR
2021-12-28
Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat
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br Introduction The fibroblast growth factor receptor FGFR p
2021-12-28
Introduction The fibroblast growth factor receptor (FGFR) pathway is an important oncogenic driver in malignant cancer. It controls cellular processes such as cell proliferation, differentiation, migration, ion channel progression, metabolism, and survival. In non–small-cell lung cancer, the mos
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For our test subjects we used
2021-12-28
For our test subjects, we used established high fat diet–induced obese (eDIO) male mices T2DM models. The establishment of eDIO mice was accomplished with a 60% high fat diet ad libitum over a 14 week period (initiated at 6 weeks of age). Compared with regularly-dieted mice, the eDIO ones weigh sign
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Arsenic is generally found in the form of iAs
2021-12-28
Arsenic is generally found in the form of iAs in arsenic plants. Arsenic is primarily metabolized in the liver through methylation processes. Human metabolism of arsenic results in the formation of the methylarsenic metabolites, MMA and DMA, which are more water soluble (Khaleghian et al., 2014; Wei
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Acknowledgments We would like to thank
2021-12-28
Acknowledgments We would like to thank Dr. Greg Morriello, Mr. Lehua Chang, Mr. Chris Moyes and Mr. Nam Fung Kar for intermediate 3 syntheses. Cheng Zhu would like to thank Dr. Milana Maletic, Mr. Kake Zhao and Mrs. Wanying Sun for helpful discussions. Introduction Glucagon-like peptide-1 (GLP-
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A linker length of and atoms was found to be
2021-12-28
A linker length of 4 and 5 atoms was found to be optimal ( and ) compared to the only weakly active compounds with longer linkers ( and ) or the inactive compounds with shorter linker chains (–). In a next step incorporation of hetero-atoms in the linker was explored (). An amide linker as in and d
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One of the possible disadvantages of this methodology is
2021-12-28
One of the possible disadvantages of this methodology is a possible cytotoxic effect resulting from either adenoviral vector injection or to Cre recombinase expression. Adenovirus has previously been used to efficiently mediate transgene expression in mouse CJ-42794 (Thomas et al., 2000, Xia et al.
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Abnormal expression and higher activity of
2021-12-28
Abnormal expression and higher activity of GLO I have been detected more in various tumor GSK-LSD1 hydrochloride than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity
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Natural products have been always the most important
2021-12-28
Natural products have been always the most important and productive sources of lead compounds for the development of drugs [[15], [16], [17]]. A variety of potent α-glucosidase inhibitors have been identified from natural products, such as quercetin, resveratrol, isorhamnetin, calein C and curcumin
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It has been well established that triazophos is a
2021-12-27
It has been well established that triazophos is a classic resurgence-inducing insecticide favoring N. lugens population growth by fecundity stimulation, with enhanced contents of soluble sugar, crude fat, soluble protein content of fat body and ovary, glucose and trehalase activity but reduced treha
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br Materials and methods br Results br Discussion Both
2021-12-27
Materials and methods Results Discussion Both EMT of the tubular epithelial 17-Hydroxyprogesterone mg and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and pathogenesis
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