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br Introduction Topological hedgehogs keep generating intere
2022-02-22
Introduction Topological hedgehogs keep generating interest in point-set topology as they are a rich source of counterexamples and applications (for a comprehensive survey on topological hedgehogs we refer to [1]; see also [9]). They may be described as a set of spines identified at a single poin
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Further SAR was explored with
2022-02-22
Further SAR was explored with the imidazole series to achieve better enzyme inhibition activity (). In comparison to published earlier, replacing the amide with sulfonamide and reverse sulfonamide maintained the GSNOR inhibitory activity. It is clear that exchanging the phenyl ring (, and ) by t
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Etoposide VP a semisynthetic podophyllotoxin derivative agen
2022-02-22
Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology
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br Medium and long chain fatty acid
2022-02-22
Medium- and long-chain fatty 3-Deazaadenosine receptors Clinical studies of ω3 fatty acids Clinical studies have established that dietary intake of ω3 fatty acids should be around 4g/day for treating very high triglyceride levels (≥5.7mmol/L) [36]. Low-dose supplementation with EPA + DHA (400
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doxercalciferol br Next we explored the SAR around
2022-02-22
Next, we explored the SAR around the aryl ring attached to the pyrrole nitrogen in the presence of the 3-CF and the 2,6-difluorophenylpropionic doxercalciferol sidechain (). The EC value of the unsubstituted phenyl was about 100 nM. The 4-methyl was 2-fold more potent, however ethyl and bromo
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br Experimental methods br Acknowledgments We thank all memb
2022-02-22
Experimental methods Acknowledgments We thank all members of the Hermanson lab, especially Ana Teixeira, Shirin Ilkhanizadeh and Karolina Wallenborg, for assistance and discussions, Peter Löw for anti-synaptotagmin antibody, and Lars Björklund, Ole Isacson, Christer Höög, Claes Wahlestedt and
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br Materials and methods br Results br Discussion
2022-02-22
Materials and methods Results Discussion Common to catfish fry production, high stocking densities as well as intensive handling during transport can result in low dissolved oxygen levels (Abdalla and Romaire, 1996; Torrans et al., 2003), which can result in fish stress. It is not known at
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The Growth Hormone Secretagogue Receptor GHSR
2022-02-22
The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in CAY10683 synthesis regions concerned with homeostatic and motivational function such as the hypot
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A frequent complication of SIRS and
2022-02-21
A frequent complication of SIRS and sepsis is the development of increased airway resistance and lung inflammation [2], [3]. For example, Uhlig et al. [3] demonstrated that rat lungs exposed to endotoxin present increased airway resistance due to constriction of terminal Benzoylmesaconitine synthesi
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br Conclusion br Conflict of interest
2022-02-21
Conclusion Conflict of interest Acknowledgements Introduction The brain contains abundant fatty acids, which serve as constituents of membranes and as an energy source. In addition, fatty acids and their metabolites contribute to signal transduction between neurons or neurons and glial c
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The urea derivatives a e were obtained from
2022-02-21
The urea derivatives 7a–e were obtained from 1-(3-phenoxybenzyl)-piperazine (6) by reaction of isocyanate, or triphosgene and subsequent reaction of produced carbamoyl chloride with the amine RH as shown in Scheme 2. The imidazole urea 7g was prepared by reaction of 6 with 1,1′-carbonyldiimidazole.
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DC260126 Assays can perform differently by genotype and unde
2022-02-21
Assays can perform differently by DC260126 and under-quantification of HCV GTs has been seen with HCV assays [8], [9], [10], [11]. Under-quantification of GT4 has been reported in some early studies of the VERIS Assay [7], [12] where a bias greater than −0.5 log10IU/mL was seen. In two more recent
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In normal tissues the expression
2022-02-21
In normal tissues, the expression patterns of GPR120 and GPR40 are not uniform. GPR120 is highly expressed in adipocytes, lung and intestinal tract, while GPR40 is shown to be expressed in pancreatic islet AC220 ic50 and intestinal tract [7], [20]. It is considered that the distribution of the GPR1
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Introduction Gestational diabetes mellitus GDM is one of the
2022-02-21
Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l
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To search for potential variants of SLA DOB
2022-02-21
To search for potential variants of SLA-DOB and CD4 associated with different (percentage) levels of the five (T-lymphocyte subsets, total antibody IgG, interferon alpha (IFN-α), Toll like receptor 3 (TLR3), interleukin 6 (IL-6) in serum and porcine reproductive and respiratory syndrome virus (PRRSV
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