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In the present study the relative
2022-03-10
In the present study, the relative mRNA Polydatin synthesis levels of CsLCCH3 and Cs8916 subunits in the egg were the highest, which were consistent with those of LsLCCH3 and Ls8916 from L. striatellus (Wei et al., 2017b) and were also similar to CsRDLs (Sheng et al., 2018; Meng et al., 2018). Over
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It raises a question about origin
2022-03-10
It raises a question about origin of the sensitivity to Ca of both FBPase isozymes. Was the ancestral vertebrate FBPase inhibited by calcium similarly to the liver isozyme? And is the high sensitivity of FBP2 a new evolutionary feature of warm-blooded vertebrates? Additionally, since subcellular lo
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Therefore the histomorphology and the comprehensive analysis
2022-03-10
Therefore, the histomorphology and the comprehensive analysis of TMJ-RA pathogenesis need to be completed although clinical findings in TMJ-RA are similar to RA in other joints [41]. Especially for the dentist, the difficulties associated with diagnosing TMJ-RA patients [49] posing challenges to dia
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In addition the interplay of membrane curvature induced tens
2022-03-10
In addition the interplay of membrane curvature induced tension at the fusion pore and octopamine induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further re
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Protionamide br Cellular transportation of nanoparticles and
2022-03-10
Cellular transportation of nanoparticles and nanocomplexes Endocytosis and exocytosis are critically important phenomena in cellular metabolism, which involve the complex vesicular system. They deal with major cellular transportation activities including membrane homeostasis by transporting prote
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In conclusion we have demonstrated that the ejection of
2022-03-10
In conclusion, we have demonstrated that the ejection of structural zinc ions from G9a and GLP in the presence of selenium-, and sulfur-containing electrophilic small cytokine inhibitors leads to inhibition of these two biomedically important epigenetic enzymes. Our work demonstrates that clinicall
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Studies have demonstrated the paradoxical role of HO in tumo
2022-03-10
Studies have demonstrated the paradoxical role of HO-1 in tumorigenesis. At initial stages of carcinogenesis, it protects DNA by lowering the ROS-mediated mutational rate, but later, HO-1 promotes cancer cell survival and proliferation. One PDAC therapeutic strategy is to increase ROS production and
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Mice lacking S nitrosoglutathione reductase GSNOR
2022-03-10
Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro
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br Author contributions br Conflict of interest
2022-03-10
Author contributions Conflict of interest Acknowledgments We appreciate technical support of the Research Support Center at the Graduate School of Medical Sciences of the Kyushu University. This study was supported by the Uehara Memorial Foundation and a KAKENHI grant from the Ministry of E
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G protein coupled receptor GPCR ligands can be classified
2022-03-09
G-protein-coupled receptor (GPCR) ligands can be classified as either orthosteric or allosteric modulators. Orthosteric and endogenous ligands bind to the same site, which is topologically distinct from the allosteric site. In general, the binding domains of different orthosteric ligands may not exa
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Lamina II SG spinal cord neurons play
2022-03-09
Lamina II (SG) spinal cord neurons play an important role in regulating nociceptive input from the periphery [20,21]. Moreover, lamina II neurons are concentrated with glycinergic or GABAergic inhibitory interneurons. Therefore, it is possible that β-alanine might modulate nociceptive transmission i
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Hippo signaling is an emerging
2022-03-09
Hippo signaling is an emerging tumor suppressor pathway that plays key roles in normal physiology and tumorigenesis through the regulation of cellular proliferation and survival [4]. In humans, YAP is over-expressed as a result of genomic amplification of the 11q22 locus in a wide spectrum of human
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L-NMMA citrate The post translational modification O GlcNAcy
2022-03-09
The post-translational modification O-GlcNAcylation is also dependent upon glucose fluctuations. O-GlcNAcylation has been linked to insulin resistance and glucose toxicity in diabetes and its comorbidities [11]. O-GlcNAcylation is a dynamic modification tightly regulated by the nutritional sensor UD
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br Methods br Results and discussion br
2022-03-09
Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian retinoid x receptor as f
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br Acknowledgements br Introduction Glucagon a amino acid
2022-03-09
Acknowledgements Introduction Glucagon, a 29-amino cyclosporin peptide, is released from the pancreatic islets, intestine and stomach. Glucagon is released under hypoglycemic conditions and then elevates blood glucose levels, serving as a major counter hormone [1]. The regulation of glucose m
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