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The cytotoxicity of these compounds against Hep B
2022-04-02
The cytotoxicity of these compounds against Hep3B cells was assessed using the MTT assay. As shown in , compounds in series and (except ), which retained the carboxyl at C-17, showed no appreciable cytotoxic activity (IC > 100 μM), whereas compounds in series (except ,) were modestly cytotoxic, indi
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6-Hydroxydopamine hydrobromide Introduction Breast cancer is
2022-04-02
Introduction Breast cancer is the most common cancer among women worldwide, representing 30% of new cancer diagnoses. In addition, it is the second leading cause of cancer deaths among women [1]. With regard to the risk of breast cancer, proper diagnosis and stratification of tumors for individuali
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We have confirmed that HO suppressed TLR
2022-04-02
We have confirmed that HO-2 suppressed TLR4/MyD88-dependent signaling by down-regulating the downstream factors (TNF-α and IL-6) in mouse cerebral vascular endothelial cells [13]. In this study, HO-2 overexpression mouse model was generated and to investigated the role of HO-2 in macrophage inflamma
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It was revealed that various injured or infected
2022-04-02
It was revealed that various injured or infected organs of Hippeastrum produce a mixture of an orange-colored chalcone and flavans which can be oxidized to red-colored dimer (Wilmowicz et al., 2014, Wink and Lehmann, 1996), preventing the penetration of injured tissues by Phoma narcissi, Botrytis ci
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Nitrosylation mediated post translational modifications of p
2022-04-02
Nitrosylation-mediated post-translational modifications of proteins through GSNOR play critical roles in modulating plant defense responses to diverse abiotic and biotic stresses (Frungillo et al., 2013, Leterrier 2011). As the most fundamental and intricate physiological process of plants, photosyn
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Two different genes encode GSK isoforms and that have very
2022-04-02
Two different genes encode GSK-3 isoforms α and β that have very similar catalytic domains but significantly differ in their N- and C-termini. The α and β isoforms split from a common precursor approximately at the emergence of vertebrates, suggesting that at least one of the isoforms took on a new
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Acute in vivo experiments were performed
2022-04-02
Acute in vivo experiments were performed in normoglycemic 129SVE mice to confirm GPR119 activation and corresponding Cy5 azide control. GIP release was utilized as a biomarker for target receptor engagement and plasma GIP levels were measured 45min after oral dosing (). Both 3 and 10mg/kg produced a
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More recently several groups have
2022-04-02
More recently, several groups have characterized a role for GPR120 signaling via omega-3 fatty acids in amelioration of alcoholic hepatic injury and non-alcoholic fatty liver disease (NAFLD) [18], [19]. Nakamoto et al. demonstrated protective effects of the omega-3 fatty depsipeptide docosahexaenoi
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One difficulty in studying gp is that it binds
2022-04-02
One difficulty in studying gp120 is that it binds to more than one receptor. Understanding how FTI 277 HCl respond to gp120 is complex because of this promiscuity. In an attempt to establish the contribution of CXCR4 in the antagonistic effect of gp120 on morphine-induced antinociception, AMD3100 w
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br Acknowledgments The financial support from the National
2022-04-01
Acknowledgments The financial support from the National Natural Science Foundation of China (Nos. 31460422 and 31060210), the Natural Science Foundation of Jiangxi Province, China (20171BAB204029 and 20143ACB20006), the Project of Science and Technology of Jiangxi Provincial Education Department,
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GK allosteric activators validate the importance of GK from
2022-04-01
GK allosteric activators validate the importance of GK from a therapeutic perspective, but the nature of allosteric activation of GK remains unclear. The GK allosteric activator site, the pocket where GKAs bind, is ~20 Å remote from the active site (Fig. 1A). The allosteric site is the locus of man
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Yeast two hybrid screening studies have provided the foundat
2022-04-01
Yeast two-hybrid screening studies have provided the foundation for countless investigations of protein-protein interactions [[141], [142], [143]]. To identify additional hepatic proteins similar to GKRP that are implicated in GCK regulation, a group of researchers conducted a two-hybrid study using
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NF 449 br Methods br Results br Discussion Among three main
2022-04-01
Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc
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LbGlcK and the HsHxKIV d glucose complex PDB entry
2022-04-01
LbGlcK and the HsHxKIV-d-glucose complex (PDB entry 3IDH) [17] were superimposed from individual subunits. The active site regions revealed the key signal transducer and activator of transcription 6 fragment mg binding residues to be present for LbGlcK; also, the superposition showed that HsHxKIV h
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As glucagon stimulated hepatic glucose production is a
2022-04-01
As glucagon-stimulated hepatic AZD5363 production is a key component of the normal response to hypoglycemia, the potential of a GCGr antagonist to delay or prevent recovery from a hypoglycemic state is a critical safety issue that must be addressed. Studies of the effects on time to recovery from a
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