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To promote biomimetic growth of HAp Li et
2022-04-11
To promote biomimetic growth of HAp, Li et al. [20] developed a technique to modify cellulose nanofibers using P2O5. It was ascertained that the negative phosphate groups bonded with Ca2+ through coordination bonds and subsequently guided the growth of the Ca–P crystals throughout the scaffolds. Sim
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br Material and methods br Results br
2022-04-11
Material and methods Results Discussion In vitro testing is necessary to study DAA activity and putative RASs. Compared to enzymatic assays and replicons, HCV infectious culture systems reflect the full viral life cycle and previous results in these systems reflected clinical data.[13], [14
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br Methods br Results br Discussion Peptide
2022-04-11
Methods Results Discussion Peptide therapeutics represents a unique class of biopharmaceuticals that continues to evolve in drug discovery and development. We and others have been particularly interested in bioengineering innovative pGC-A and/or pGC-B peptide activators. This has been succe
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In contrast to RhoA Rac and Rap
2022-04-11
In contrast to RhoA, Rac1 and Rap1 which are stimulated by platelet activators and inhibited by NO/PKG, the GTPase ADP-ribosylation factor 6 (Arf6) is regulated in the reverse way. Platelet agonists like thrombin, collagen, or ADP, reduce Arf6-GTP levels, whereas NO and PGI2 oppose this reduction [1
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ack1 inhibitor TRAPP Transport Protein Particle complexes sh
2022-04-11
TRAPP (Transport Protein Particle) complexes share a common core architecture and function in ack1 inhibitor and autophagy (Kim et al., 2016). In yeast, the core complex has GEF activity for the Rab1 ortholog Ypt1. The larger TRAPPII and III complexes include regulatory subunits implicated in membra
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Studies with GSNOR knockout mice
2022-04-11
Studies with GSNOR knockout mice reported decreased CD4+ pak 4 and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO treated mice, w
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Hypoxia has been shown to affect miR expression that can
2022-04-11
Hypoxia has been shown to affect miR-155 expression that can induce autophagy in nasopharyngeal and cervical carcinoma cells [334]. Suppression of miR-155 inhibited hypoxia-induced autophagy. miR-155 targeted mRNAs involved in the PI3K/PTEN/Akt/mTORC1 pathway including: Ras homolog enriched in nelfi
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br Materials and methods br Results br Discussion In
2022-04-11
Materials and methods Results Discussion In this report, we have analyzed the function of an orphan GPCR, and GPR84, using genetically-deficient mice. The expression of GPR84 in the T and NVP-BKM120 Hydrochloride in the spleen prompted us to examine the functional responses of these cells u
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The ketone body receptor HCA is most
2022-04-11
The ketone body receptor HCA2 is most likely not active under normal conditions, since local levels and plasma levels of ketone bodies such as β-HB are too low to activate the receptor. However, overnight fasting or prolonged starvation results in plasma levels of the ketone body in the millimolar r
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Molecular modeling studies also revealed insignificant diffe
2022-04-11
Molecular modeling studies also revealed insignificant differences in ligand-receptor interaction energies between R and S enantiomers of LPCs or their 2-OMe-analogues, suggesting that enantiomers of a particular structure should exert similar GPR119-mediated biological effect. Indeed, when studied
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Based on the precedent with other GlyT inhibitors such as
2022-04-11
Based on the precedent with other GlyT1 inhibitors such as , we evaluated both and for their ability to enhance prepulse inhibition (PPI) of the rodent acoustic startle response, a measure of sensorimotor gating known to be deficient in schizophrenic patients., In this dofetilide study (), both and
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The unique ability of R PabI to specifically excise adenine
2022-04-11
The unique ability of R.PabI to specifically excise AG-490 mg from a palindromic sequence is based on a novel structural architecture that is distinct not only from other DNA glycosylases but also from other proteins [88]. In the absence of DNA, R.PabI forms a dimer with a central, highly twisted β-
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First class II fusion proteins are known to transition
2022-04-11
First, class II fusion proteins are known to transition from a (homo- or hetero-) pre-fusion dimer to a post-fusion trimer [57], [58], [59], [60], [61], [62] through a monomeric intermediate [63], [64], and a crystalline structure of a monomer of Rift Valley fever virus (a phlebovirus, member of the
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Several studies have found decreased astroglial and neuronal
2022-04-11
Several studies have found decreased astroglial and neuronal cell numbers and azd9291 damage after OP exposure. Neuronal loss and brain lesions increase proportionally to the severity and duration of OP-induced seizures (Albuquerque et al., 2006, Carpentier et al., 2000, Gullapalli et al., 2010, My
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The expression of GLUT receptors throughout the body could
2022-04-09
The expression of GLUT receptors throughout the body could be considered a potential source for off-target effects even for engineered glucose-conjugated nanomedicines, as there are at least 12 types of GLUT transporters in the body, including GLUT1 in erythrocytes and the blood-brain barrier, as we
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