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br Discussion Light plays a central role in
2022-05-20
Discussion Light plays a central role in plant growth, development and defence responses. It is required for photosynthesis and other metabolic or transcriptional processes (Kangasjärvi et al., 2012, Zhang and Zhou, 2013, Ballaré, 2014). It is well known that darkness promotes leaf senescence, wh
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Given the major differences between the molecular regulation
2022-05-20
Given the major differences between the molecular regulation of the genes encoding HO-1 (HMOX1) in mice and humans, it is not appropriate to utilize mouse models for mechanistic analyses of human HMOX1[35]. In addition, it has been reported that drugs, such as statins, as well as stressors and the r
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57 100 Lieber have discussed alcohol outside the
2022-05-20
Lieber (2000), have discussed alcohol outside the context of hepatitis C infection exerts specific pathologic effects on the liver. Liver biopsies in patients with hepatitis C who drink alcohol are generally consistent with hepatitis C alone, with portal-based pathology, rather than alcoholic injury
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Analysis of the thermosensory responses conferred by chimeri
2022-05-20
Analysis of the thermosensory responses conferred by chimeric proteins suggests that both the ECD and ICD of AFD-rGCs contribute to their thermoresponsive properties. The presence of the GCY-18 or GCY-23 ICD and TMD in chimeric protein combinations generally corresponds to a higher or lower , respec
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Our results show furthermore that higher concentrations
2022-05-20
Our results show furthermore, that higher concentrations of butyric Sumatriptan additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of GSTP1 expressi
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br Conclusion br Conflict of interest br References and
2022-05-20
Conclusion Conflict of interest References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Free fatty acids (FFAs) are essential nutrients that contribute to various cellular functio
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99026 synthesis The difference in the expression
2022-05-20
The difference in the expression of functional FFARs between neutrophils and monocytes/macrophages suggests that the role of FFA2R may be restricted to the very early phase of acute inflammation where neutrophils are dominating players called into action, whereas GPR84 may have a broader functional
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br Conclusions In summary we have designed
2022-05-20
Conclusions In summary, we have designed an ultrasensitive electrochemical assay for hOGG1 based on a ratiometric strategy and HCR assisted amplification. The hOGG1 can specifically identify 8-oxo G site on the DNA probes modified on the electrode surface. The subsequent cleavage reaction trigger
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Hepatic drug metabolizing enzymes and transporters expressio
2022-05-19
Hepatic drug-metabolizing ON123300 and transporters expression were regulated by nuclear receptors [19], [20], [21]. The effects of HFD-induced fatty liver on drug metabolizing enzymes in mice were recently studied, and the results provided a systematic evaluation of the changes of nuclear receptor
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In order to consolidate our
2022-05-19
In order to consolidate our genetic funding, we performed several in silico analysis regarding the p.R85W mutation. The high conservation of R85 residue in all species suggests that it has an important role in glucokinase function. Pathogenic effect of the p.R85W is supported by in silico prediction
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br Indirect GLI antagonists br Direct GLI antagonists br
2022-05-19
Indirect GLI antagonists Direct GLI antagonists Concluding remarks Targeting GLI effectors represents a promising therapeutic strategy for cancer treatment. This is particularly relevant for certain tumors, such as MB, since, although classified into four distinct molecular groups (Hh- or W
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Gastric inhibitory polypeptide a hormone
2022-05-19
Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression
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Analysis of the GHSR screening
2022-05-19
Analysis of the GHSR screening data for inactive library members indicated that the prolinol-derived secondary amine and α-substituted phenoxyacetamide moieties described in were critical for activity. As a result, we initiated the synthesis of follow-up libraries utilizing the solid-phase chemistry
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Though regulation of ghrelin interaction with
2022-05-19
Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot
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A model substance often used in
2022-05-19
A model substance often used in the studies of oxidative processes in erythrocytes is tert-butyl hydroperoxide (t-BHP), which, being lipophilic, passes easily across the erythrocyte membrane [9]. In erythrocytes treated with t-BHP (0.1–3mM) for less than 1h, a dramatic decline in the reduced glutath
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