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br Acknowledgments This work was supported
2022-06-29
Acknowledgments This work was supported by the Slovak grant agency VEGA, Grant 2/0084/13. We would like to thank Dr. J. Bauer for careful reading of the manuscript. Introduction Glycine is an important neurotransmitter which regulates both jak stat pathway inhibitory neurotransmission and ex
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br Materials and methods br Results
2022-06-29
Materials and methods Results Discussion Conclusion Pharmacophore modeling was applied to explore new probable Glo-I inhibitors. Ninety two pharmacophoric models were generated representing diverse types of interaction between co-crystallized ligands and corresponding binding site. The g
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Recent research reveals that human alkyladenine DNA glycosyl
2022-06-29
Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in topoisomer
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This resembles a vicious cycle since BBB disruption and infl
2022-06-29
This resembles a vicious cycle since BBB disruption and inflammation are thought to be caused by epilepsy, but other contributing factors are also known to be their cause, such as peripheral infection, autoimmunity, 5-fu trauma and stroke that also underlie epilepsy [18]. Additional triggers that s
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br Transporter based brain targeting nano DDS
2022-06-29
Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the O-1602 from harmful substances. Since only selected, neutral, lipophilic small molecu
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br Author contribution br Declaration of interest br Acknowl
2022-06-29
Author contribution Declaration of interest Acknowledgements This work was supported by National Natural Science Foundation of China (Grants 81473093) and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM1601ZZ-02). Introduction Diabetes represents a majo
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In glioma or glial derived primary brain
2022-06-29
In glioma, or glial-derived primary phospholipase a2 inhibitor tumors, as in other cancers, glutathione is an important survival mechanism. Glioma cells are dependent upon SXC-mediated cystine uptake for viability, as they require intracellular cystine/cysteine for GSH synthesis (Ogunrinu and Sonth
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Regarding the causative diseases of
2022-06-29
Regarding the causative diseases of ES, patients with unknown cause and those with encephalitis had significantly higher CSF levels of gstp1 against GluN2B-NT2 and GluN2B-CT than the disease controls, but patients with genetic disorder and those with cortical dysplasia showed no significant differe
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Introduction As per WHO report in more than million peoples
2022-06-29
Introduction As per WHO report, in 2014 more than 422 million peoples were living with diabetes and according to International Diabetes Federation, by 2045 this figure would reach 693 million [1,2]. Diabetes, a fast growing major health problem, is common chronic, metabolic disease characterized by
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br Acknowledgments The financial support from the National
2022-06-29
Acknowledgments The financial support from the National Natural Science Foundation of China (Nos. 31460422 and 31060210), the Natural Science Foundation of Jiangxi Province, China (20171BAB204029 and 20143ACB20006), the Project of Science and Technology of Jiangxi Provincial Education Department,
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The MeO CFO phen yl group was then selected
2022-06-29
The 1-MeO-4-CFO-phen-2-yl group was then selected for the C-3 position when we investigated the aryl substituents at the C-6 position of indazole. As shown in , C-6 position seems to be more tolerant than the C-3 position, as all the aryl groups examined exhibited potent hGCGR activity. Interestingl
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Clodronate Disodium It was previously proposed that glucagon
2022-06-29
It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the Clodronate Disodium via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in
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br Acknowledgements br Introduction Ghrelin is
2022-06-29
Acknowledgements Introduction Ghrelin is a potent orexigenic hormone and growth hormone secretagogue mainly derived from the stomach [1], [2], [3], [4], [5]. Other pleiotropic actions of the hormone include those that are glucoregulatory, food reward-enhancing, gastric motility-enhancing, and
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Importantly bioelectric circuits in tissues Fig A have a cap
2022-06-29
(4) Importantly, bioelectric circuits in tissues (Fig. 2A) have a capacity to store long-term patterning information. An example is planarian anterior-posterior patterning: during regeneration, each fragment cut from a worm needs to build a head and tail at their correct ends. This process is regula
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The G protein coupled receptor GPR also called FFAR
2022-06-29
The G protein-coupled receptor, GPR40 (also called FFAR1) responds to medium and long chain unsaturated fatty acids, resulting in increase of insulin secretion during elevated glucose levels. The glucose dependency of insulin secretion makes this receptor a very good target for developing therapies
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