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GSTP is a class Glutathione
2022-07-27
GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting Refametinib against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in prostate carcinogen
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One previously unreported discovery is that Ptgds is
2022-07-27
One previously unreported discovery is that Ptgds is alternatively spliced, such that partial removal of exon 3 correlates with higher levels of regeneration. The absence of exon 3 likely affects the functionality of the final product. The structure of Ptgds is that of the typical lipocalin β-barrel
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In summary through medicinal chemistry design and
2022-07-27
In summary, through medicinal chemistry design and computer-assisted conformational modeling, the initial lead was evolved into a series of dihydrobenzofuran derivatives, , as potent GPR119 agonists. Optimization of general structure at various regions of the molecule, including the substituent on
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br Materials and methods br Results and discussion
2022-07-27
Materials and methods Results and discussion Conclusion A new label-free targeted methodology using two-step fractionation coupled with conventional microflow LC-MS/MS was developed and validated to profile 54 selected clinically relevant human plasma glycoproteins. The developed method has
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br Results br Discussion We have reported the
2022-07-27
Results Discussion We have reported the crystal structures of VcmN, the high-resolution structures of this MATE transporter from a pathogenic bacterium. The structures display distinct conformations of TM1, as a consequence of their unique hydrogen-bonding networks. We interpret this result to
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br Introduction Cherry tomato Solanum lycopersicum
2022-07-27
Introduction Cherry tomato (Solanum lycopersicum L.) is a commonly consumed fruit on a worldwide scale due to its characteristic flavor and high nutrition (Wei et al., 2016, Yu et al., 2014). Tomato is low in fat and calories, and is a rich natural source of nutrition and bioactive antioxidant co
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br Materials and methods br Results br Discussion The glucos
2022-07-27
Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast GS-1101 by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minutes and w
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hcv protease inhibitors br Vertebrate steroid receptor evolu
2022-07-27
Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th
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br Results br Discussion ER and
2022-07-27
Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in
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The first report about the activity of ANAM
2022-07-27
The first report about the activity of ANAM in CACs it is due to Garcia et al. [19] which treated 16 cancer patients with oral ANAM 50mg once daily vs placebo for 3days followed by a washout AZD-4547 synthesis of 5–7days and then cross-over to the other group for 3 more days. It was described a wei
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FPR activation stimulates multiple signal transduction pathw
2022-07-27
FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, Fmoc-Phe-OPfp of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflammatory response a
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br Concluding Remarks One of
2022-07-26
Concluding Remarks One of the remarkable features of Hippo signaling is its sensitivity to the cytoskeleton and mechanical forces. Progress has been made recently in identifying molecular mechanisms by which the cytoskeleton can influence Hippo signaling, but among the many outstanding questions
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microRNAs miRNAs of approximately nucleotides play vital
2022-07-26
microRNAs (miRNAs) of approximately 22 nucleotides play vital roles in cancer development and progression by regulating translational repression or decay of target messenger RNAs (mRNAs) through their binding to the 3′-untranslated regions (3′-UTRs) of target mRNAs with imprecise or precise compleme
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Hexokinases HXKs are major regulatory
2022-07-26
Hexokinases (HXKs) are major regulatory enzymes in sugar metabolism and in sugar sensing in plants (Claeyssen and Rivoal, 2007, Granot et al., 2013, Sheen, 2014, Aguilera-Alvarado and Sánchez-Nieto, 2017). HXK can phosphorylate both glucose and fructose to respective hexose-6-phosphates as a first s
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br Conflict of interest statement
2022-07-26
Conflict of interest statement Introduction The Hedgehog (Hh) family of secreted protein signals patterns many tissues and structures during embryogenesis (Chiang et al., 1996, Dessaud et al., 2008, Ingham, 1993) and, post-embryonically, governs tissue homeostasis and regeneration by regulatin
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