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Several plant derived molecules such as
2022-08-04
Several plant-derived molecules such as resveratrol, curcumin, zerumbone, and physalin B have been reported as modulators of Hh/Gli signaling pathway (Hosoya et al., 2008, Mohapatra et al., 2015). Our previous studies have demonstrated that a sesquiterpene lactone and diarylheptanoids from Siegesbec
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An isoflavone type secondary metabolite Glabrescione
2022-08-04
An isoflavone type secondary metabolite, Glabrescione B (GlaB), from Derris glabrescens (Benth.) J.F. Macbr. from the family Fabaceae, was found to possess the capacity to bind the Gli1 zinc finger domain and to further block DNA binding capacity [118]. Pyrvinium, an anthelmintic drug approved by th
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br Materials and methods br Results br Discussion
2022-08-04
Materials and methods Results Discussion Myocardium reperfusion injury contributes almost half of myocardial infarct size in myocardial infarction patients, and infarct size is closely correlated with the probability of developing hif pathway failure [1]. Despite this knowledge, myocardial
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In the present study we focused on a
2022-08-04
In the present study, we focused on a role of the C-terminal segment in GCAP2 using two chimeric proteins, in which the C-terminal segment of GCAP2 was either replaced by the corresponding sequence of recoverin (chimera GR) or transferred into recoverin (chimera RG). We have monitored Ca-dependent c
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The expression of COX has
2022-08-04
The expression of COX-2 has been correlated with the density of amyloid plaque [65]. A study reported that IMX was effective in suppressing the expression of iNOS and IL-6, but not COX-2, in LPS-stimulated BV2 microglial cells [52]. In this study, IMX did not alter upregulation of COX-2 induced by H
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It was reported that GPR
2022-08-04
It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive Disulfiram in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages (Hori
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Introduction Gestational diabetes mellitus GDM is one of the
2022-08-04
Introduction Gestational diabetes mellitus (GDM) is one of the most common complications associated with pregnancy [1]. Approximately 7.6% of pregnancies in the United States are complicated by GDM [2,3], which significantly increases the mother's risk of developing type 2 diabetes (T2D) later in l
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On the other hand it is
2022-08-04
On the other hand, it is quite possible that strychnine-sensitive glycine sites are responsible for mediating the anticonvulsant effects of GlyT1 inhibitors. Strychnine, which acts as an antagonist at these sites, is a well-known as a convulsant drug, and elevation of endogenous glycine levels at th
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Introduction Cancer is known as a renegade
2022-08-04
Introduction Cancer is known as a renegade system of expansion that initiate in human body. It is distinguished, in spite of its category, by one universal characteristic, which is uncontrolled cell division. Cancerous 7026 mg have the ability to bypass the normal apoptosis mechanism (National Can
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br Materials and methods br Results br Discussion
2022-08-03
Materials and methods Results Discussion Common to catfish fry production, high stocking densities as well as intensive handling during transport can result in low dissolved oxygen levels (Abdalla and Romaire, 1996; Torrans et al., 2003), which can result in fish stress. It is not known at
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While CART increased circulating levels of GIP and GLP in
2022-08-03
While CART increased circulating levels of GIP and GLP-1 in vivo, we were unable to detect any effect of exogenous CART on GIP and GLP-1 mRNA expression or GLP-1 secretion in vitro. There is no ready explanation for this discrepancy. The CART doses used (both in vivo and in vitro) have been shown to
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br Structures of human secretase Before the near
2022-08-03
Structures of human γ-secretase Before the near-atomic resolution structures, the highest resolutions achieved for γ-secretase were 15 and 12Å [19, 21]. The 15-Å structure revealed a 67 8 chamber in the transmembrane domain and two pores at the top and bottom of γ-secretase, which were speculate
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Introduction Initially postulated to represent the
2022-08-03
Introduction Initially postulated to represent the main source of ATP production in eukaryotic cells, mitochondria are recently recognized to perform manifold essential functions beyond energy production, impacting most areas of cell biology and medicine [1]. Mitochondrial metabolism is both the ba
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We note that zinc speciation at and mol
2022-08-03
We note that zinc speciation at 0 and 2 mol. equiv. of myristate is already markedly different; this means that FFAZn2+ crosstalk is in operation under normal physiological conditions. At present, there are few data to allow tracking of the effects of such physiological crosstalk, although there are
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br Results br Discussion Immune mediated chronic inflammator
2022-08-03
Results Discussion Immune-mediated chronic inflammatory diseases (e.g. rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel disease) are characterized by a dysregulated migration of leukocytes from blood vessels into inflamed tissues. To date, several new targets and inh
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