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In contrast to short term effects
2022-08-09
In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty Fluorouracil oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (ER) str
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In general the FDP gene
2022-08-08
In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in
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Chi square tests with significance set to p were used
2022-08-08
Chi-square tests with significance set to p Results There were 4090 hip fracture patients included in the study. 2326 of these received enoxaparin, 929 received XaI, and 835 received warfarin. The mean CCI for each group was 3 (Table 2). There were some significant differences in demographics betw
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With the aim to identify
2022-08-08
With the aim to identify potential novel targets in CVD, we applied proteome analyses on vascular tissue of these frequently used mouse models of atherosclerotic disease in the presence and/or absence of diabetes. Potential targets for intervention identified with this approach were validated in hu
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In this study there is a limitation in the study
2022-08-05
In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual N1-Methylpseudouridine emptying was needed until reflex bladder emptying was established (Lu et al., 2008, Ma et al.,
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MRS1523 synthesis br Introduction Circulating tumor cells CT
2022-08-05
Introduction Circulating tumor MRS1523 synthesis (CTCs) are cancer cells that have invaded blood vessels or lymphatics and are carried around the body by the blood. CTCs constitute potential seeds for metastasis because they can reach and implant into distant organs. The clinical importance of C
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Oseltamivir phosphate As a possible back up
2022-08-05
As a possible back-up to Sch 503034 (), we explored inhibitors that contained alternative electrophiles to ketoamides. Boronic acids have been extensively investigated as possible electrophiles that could react with nucleophilic serine in the context of developing inhibitors of thrombin receptor and
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Interestingly myorelaxation and the stimulation of cGMP
2022-08-05
Interestingly, myorelaxation and the stimulation of cGMP production are properties also reported for sGC stimulators, such as YC-1 and BAY 41–2272 (i.e., indazole compounds that were discovered in the 1990s) [35]. They relax aortic ring contractions induced by phenylephrine, and their effects are si
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GSK1016790A Studies of human and mouse GPR as ascertained
2022-08-05
Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl
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br GPR a G protein coupled receptor
2022-08-05
GPR35, a G protein-coupled receptor (GPCR), was discovered and classified as an orphan GPCR in 1998 and deorphanized in 2006 by the discovery of kynurenic Nemadectin as the endogenous agonist. Since its discovery, limited references on the GPR35 receptor have appeared, due in part to a scarcity o
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prostaglandin e synthesis br Next we explored the
2022-08-05
Next, we explored the SAR around the aryl ring attached to the pyrrole nitrogen in the presence of the 3-CF and the 2,6-difluorophenylpropionic prostaglandin e synthesis sidechain (). The EC value of the unsubstituted phenyl was about 100 nM. The 4-methyl was 2-fold more potent, however ethyl
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br Experimental br Results br Discussion The use
2022-08-05
Experimental Results Discussion The use of Dex-BSA asa membrane-limited glucocorticoid has been met with some skepticism, mainly for its assumed instability. Here we provide conclusive evidence that Dex-BSA is stable in solution over an extended period of time and at high temperature (i.e.,
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br Nanoscale Cortical Actin Remodeling in
2022-08-04
Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical FPS-ZM1 sale is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well established, the funct
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Consistent with a similar study we found economic status
2022-08-04
Consistent with a similar study, we found economic status to be very important to domestic funding of HIV. Upper-middle-income and high-income countries are more likely to have fiscal space for health and be less reliant on external sources. Moreover, richer countries often attract larger cofinancin
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To interrogate the molecular basis for the
2022-08-04
To interrogate the molecular basis for the myocardial phenotype in mutant hearts, we performed quantitative real-time PCR (qRT-PCR) expression analysis of genes encoding critical endocardium-derived molecules including Nrg1 and Efnb2. Nrg1 expression was reduced in E13.5 mutant hearts as compared to
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